The architecture and evolution of cancer neochromosomes.
Identifieur interne : 003450 ( Main/Exploration ); précédent : 003449; suivant : 003451The architecture and evolution of cancer neochromosomes.
Auteurs : Dale W. Garsed [Australie] ; Owen J. Marshall [Australie] ; Vincent D A. Corbin [Australie] ; Arthur Hsu [Australie] ; Leon Di Stefano [Australie] ; Jan Schröder [Australie] ; Jason Li [Australie] ; Zhi-Ping Feng [Australie] ; Bo W. Kim [Australie] ; Mark Kowarsky [Australie] ; Ben Lansdell [Australie] ; Ross Brookwell [Australie] ; Ola Myklebost [Norvège] ; Leonardo Meza-Zepeda [Norvège] ; Andrew J. Holloway [Australie] ; Florence Pedeutour [France] ; K H Andy Choo [Australie] ; Michael A. Damore [États-Unis] ; Andrew J. Deans [Australie] ; Anthony T. Papenfuss [Australie] ; David M. Thomas [Australie]Source :
- Cancer cell [ 1878-3686 ] ; 2014.
Descripteurs français
- KwdFr :
- Aberrations des chromosomes, Carcinogenèse (génétique), Centromère (génétique), Chromosomes humains (génétique), Femelle, Humains, Lignée cellulaire tumorale, Liposarcome (anatomopathologie), Liposarcome (génétique), Modèles génétiques, Mutagenèse, Oncogènes, Sujet âgé, Translocation génétique, Tumeurs du rétropéritoine (anatomopathologie), Tumeurs du rétropéritoine (génétique).
- MESH :
- anatomopathologie : Liposarcome, Tumeurs du rétropéritoine.
- génétique : Carcinogenèse, Centromère, Chromosomes humains, Liposarcome, Tumeurs du rétropéritoine.
- Aberrations des chromosomes, Femelle, Humains, Lignée cellulaire tumorale, Modèles génétiques, Mutagenèse, Oncogènes, Sujet âgé, Translocation génétique.
English descriptors
- KwdEn :
- Aged, Carcinogenesis (genetics), Cell Line, Tumor, Centromere (genetics), Chromosome Aberrations, Chromosomes, Human (genetics), Female, Humans, Liposarcoma (genetics), Liposarcoma (pathology), Models, Genetic, Mutagenesis, Oncogenes, Retroperitoneal Neoplasms (genetics), Retroperitoneal Neoplasms (pathology), Translocation, Genetic.
- MESH :
Abstract
We isolated and analyzed, at single-nucleotide resolution, cancer-associated neochromosomes from well- and/or dedifferentiated liposarcomas. Neochromosomes, which can exceed 600 Mb in size, initially arise as circular structures following chromothripsis involving chromosome 12. The core of the neochromosome is amplified, rearranged, and corroded through hundreds of breakage-fusion-bridge cycles. Under selective pressure, amplified oncogenes are overexpressed, while coamplified passenger genes may be silenced epigenetically. New material may be captured during punctuated chromothriptic events. Centromeric corrosion leads to crisis, which is resolved through neocentromere formation or native centromere capture. Finally, amplification terminates, and the neochromosome core is stabilized in linear form by telomere capture. This study investigates the dynamic mutational processes underlying the life history of a special form of cancer mutation.
DOI: 10.1016/j.ccell.2014.09.010
PubMed: 25517748
Affiliations:
- Australie, France, Norvège, États-Unis
- Californie, Victoria (État), Østlandet
- Melbourne, Oslo
- Université de Melbourne
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Le document en format XML
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Kim</name><affiliation wicri:level="4"><nlm:affiliation>Chromosome Research, Murdoch Childrens Research Institute, and Department of Paediatrics, Royal Children's Hospital, University of Melbourne, Parkville, VIC 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Chromosome Research, Murdoch Childrens Research Institute, and Department of Paediatrics, Royal Children's Hospital, University of Melbourne, Parkville, VIC 3052</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Kowarsky, Mark" sort="Kowarsky, Mark" uniqKey="Kowarsky M" first="Mark" last="Kowarsky">Mark Kowarsky</name><affiliation wicri:level="1"><nlm:affiliation>Bioinformatics Division, The Walter & Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Bioinformatics Division, The Walter & Eliza Hall Institute of Medical Research, Parkville, VIC 3052</wicri:regionArea><wicri:noRegion>VIC 3052</wicri:noRegion></affiliation></author><author><name sortKey="Lansdell, Ben" sort="Lansdell, Ben" uniqKey="Lansdell B" first="Ben" last="Lansdell">Ben Lansdell</name><affiliation wicri:level="1"><nlm:affiliation>Bioinformatics Division, The Walter & Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Bioinformatics Division, The Walter & Eliza Hall Institute of Medical Research, Parkville, VIC 3052</wicri:regionArea><wicri:noRegion>VIC 3052</wicri:noRegion></affiliation></author><author><name sortKey="Brookwell, Ross" sort="Brookwell, Ross" uniqKey="Brookwell R" first="Ross" last="Brookwell">Ross Brookwell</name><affiliation wicri:level="1"><nlm:affiliation>Sullivan Nicolaides Pathology, Indooroopilly, QLD 4068, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Sullivan Nicolaides Pathology, Indooroopilly, QLD 4068</wicri:regionArea><wicri:noRegion>QLD 4068</wicri:noRegion></affiliation></author><author><name sortKey="Myklebost, Ola" sort="Myklebost, Ola" uniqKey="Myklebost O" first="Ola" last="Myklebost">Ola Myklebost</name><affiliation wicri:level="1"><nlm:affiliation>Department of Tumor Biology, Oslo University Hospital, Norwegian Radium Hospital, Oslo 0424, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Tumor Biology, Oslo University Hospital, Norwegian Radium Hospital, Oslo 0424</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Meza Zepeda, Leonardo" sort="Meza Zepeda, Leonardo" uniqKey="Meza Zepeda L" first="Leonardo" last="Meza-Zepeda">Leonardo Meza-Zepeda</name><affiliation wicri:level="1"><nlm:affiliation>Department of Tumor Biology, Oslo University Hospital, Norwegian Radium Hospital, Oslo 0424, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Tumor Biology, Oslo University Hospital, Norwegian Radium Hospital, Oslo 0424</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Holloway, Andrew J" sort="Holloway, Andrew J" uniqKey="Holloway A" first="Andrew J" last="Holloway">Andrew J. Holloway</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Genomics, Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Genomics, Peter MacCallum Cancer Centre, East Melbourne, VIC 3002</wicri:regionArea><wicri:noRegion>VIC 3002</wicri:noRegion></affiliation></author><author><name sortKey="Pedeutour, Florence" sort="Pedeutour, Florence" uniqKey="Pedeutour F" first="Florence" last="Pedeutour">Florence Pedeutour</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Solid Tumors Genetics, Nice University Hospital, Nice 06107, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratory of Solid Tumors Genetics, Nice University Hospital, Nice 06107</wicri:regionArea><wicri:noRegion>06107</wicri:noRegion><wicri:noRegion>06107</wicri:noRegion></affiliation></author><author><name sortKey="Choo, K H Andy" sort="Choo, K H Andy" uniqKey="Choo K" first="K H Andy" last="Choo">K H Andy Choo</name><affiliation wicri:level="4"><nlm:affiliation>Chromosome Research, Murdoch Childrens Research Institute, and Department of Paediatrics, Royal Children's Hospital, University of Melbourne, Parkville, VIC 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Chromosome Research, Murdoch Childrens Research Institute, and Department of Paediatrics, Royal Children's Hospital, University of Melbourne, Parkville, VIC 3052</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Damore, Michael A" sort="Damore, Michael A" uniqKey="Damore M" first="Michael A" last="Damore">Michael A. Damore</name><affiliation wicri:level="2"><nlm:affiliation>Amgen, Thousand Oaks, CA 91320, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Amgen, Thousand Oaks, CA 91320</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Deans, Andrew J" sort="Deans, Andrew J" uniqKey="Deans A" first="Andrew J" last="Deans">Andrew J. Deans</name><affiliation wicri:level="1"><nlm:affiliation>St Vincent's Institute, Fitzroy, VIC 3065, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>St Vincent's Institute, Fitzroy, VIC 3065</wicri:regionArea><wicri:noRegion>VIC 3065</wicri:noRegion></affiliation></author><author><name sortKey="Papenfuss, Anthony T" sort="Papenfuss, Anthony T" uniqKey="Papenfuss A" first="Anthony T" last="Papenfuss">Anthony T. Papenfuss</name><affiliation wicri:level="4"><nlm:affiliation>Bioinformatics Division, The Walter & Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, VIC 3010, Australia; Department of Mathematics and Statistics, University of Melbourne, VIC, 3010, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, VIC 3010, Australia; Bioinformatics and Cancer Genomics, Peter MacCallum Cancer Centre, East Melbourne, VIC, 3002, Australia. Electronic address: papenfuss@wehi.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Bioinformatics Division, The Walter & Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, VIC 3010, Australia; Department of Mathematics and Statistics, University of Melbourne, VIC, 3010, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, VIC 3010, Australia; Bioinformatics and Cancer Genomics, Peter MacCallum Cancer Centre, East Melbourne, VIC, 3002</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Thomas, David M" sort="Thomas, David M" uniqKey="Thomas D" first="David M" last="Thomas">David M. Thomas</name><affiliation wicri:level="4"><nlm:affiliation>Cancer Genomics, Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, VIC 3010, Australia; The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia. Electronic address: d.thomas@garvan.org.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Genomics, Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, VIC 3010, Australia; The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, NSW 2010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25517748</idno><idno type="pmid">25517748</idno><idno type="doi">10.1016/j.ccell.2014.09.010</idno><idno type="wicri:Area/PubMed/Corpus">003317</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003317</idno><idno type="wicri:Area/PubMed/Curation">003207</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003207</idno><idno type="wicri:Area/PubMed/Checkpoint">003207</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003207</idno><idno type="wicri:Area/Ncbi/Merge">002108</idno><idno type="wicri:Area/Ncbi/Curation">002108</idno><idno type="wicri:Area/Ncbi/Checkpoint">002108</idno><idno type="wicri:Area/Main/Merge">003464</idno><idno type="wicri:Area/Main/Curation">003450</idno><idno type="wicri:Area/Main/Exploration">003450</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The architecture and evolution of cancer neochromosomes.</title><author><name sortKey="Garsed, Dale W" sort="Garsed, Dale W" uniqKey="Garsed D" first="Dale W" last="Garsed">Dale W. Garsed</name><affiliation wicri:level="4"><nlm:affiliation>Cancer Genomics, Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, VIC 3010, Australia; Department of Pathology, University of Melbourne, VIC 3010, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Genomics, Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, VIC 3010, Australia; Department of Pathology, University of Melbourne, VIC 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Marshall, Owen J" sort="Marshall, Owen J" uniqKey="Marshall O" first="Owen J" last="Marshall">Owen J. Marshall</name><affiliation wicri:level="4"><nlm:affiliation>Chromosome Research, Murdoch Childrens Research Institute, and Department of Paediatrics, Royal Children's Hospital, University of Melbourne, Parkville, VIC 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Chromosome Research, Murdoch Childrens Research Institute, and Department of Paediatrics, Royal Children's Hospital, University of Melbourne, Parkville, VIC 3052</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Corbin, Vincent D A" sort="Corbin, Vincent D A" uniqKey="Corbin V" first="Vincent D A" last="Corbin">Vincent D A. Corbin</name><affiliation wicri:level="4"><nlm:affiliation>Bioinformatics Division, The Walter & Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, VIC 3010, Australia; Bioinformatics and Cancer Genomics, Peter MacCallum Cancer Centre, East Melbourne, VIC, 3002, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Bioinformatics Division, The Walter & Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, VIC 3010, Australia; Bioinformatics and Cancer Genomics, Peter MacCallum Cancer Centre, East Melbourne, VIC, 3002</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Hsu, Arthur" sort="Hsu, Arthur" uniqKey="Hsu A" first="Arthur" last="Hsu">Arthur Hsu</name><affiliation wicri:level="1"><nlm:affiliation>Bioinformatics Division, The Walter & Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Bioinformatics Division, The Walter & Eliza Hall Institute of Medical Research, Parkville, VIC 3052</wicri:regionArea><wicri:noRegion>VIC 3052</wicri:noRegion></affiliation></author><author><name sortKey="Di Stefano, Leon" sort="Di Stefano, Leon" uniqKey="Di Stefano L" first="Leon" last="Di Stefano">Leon Di Stefano</name><affiliation wicri:level="1"><nlm:affiliation>Bioinformatics Division, The Walter & Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Bioinformatics Division, The Walter & Eliza Hall Institute of Medical Research, Parkville, VIC 3052</wicri:regionArea><wicri:noRegion>VIC 3052</wicri:noRegion></affiliation></author><author><name sortKey="Schroder, Jan" sort="Schroder, Jan" uniqKey="Schroder J" first="Jan" last="Schröder">Jan Schröder</name><affiliation wicri:level="4"><nlm:affiliation>Bioinformatics Division, The Walter & Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, VIC 3010, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Bioinformatics Division, The Walter & Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, VIC 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Li, Jason" sort="Li, Jason" uniqKey="Li J" first="Jason" last="Li">Jason Li</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Genomics, Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Genomics, Peter MacCallum Cancer Centre, East Melbourne, VIC 3002</wicri:regionArea><wicri:noRegion>VIC 3002</wicri:noRegion></affiliation></author><author><name sortKey="Feng, Zhi Ping" sort="Feng, Zhi Ping" uniqKey="Feng Z" first="Zhi-Ping" last="Feng">Zhi-Ping Feng</name><affiliation wicri:level="4"><nlm:affiliation>Bioinformatics Division, The Walter & Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, VIC 3010, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Bioinformatics Division, The Walter & Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, VIC 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Kim, Bo W" sort="Kim, Bo W" uniqKey="Kim B" first="Bo W" last="Kim">Bo W. Kim</name><affiliation wicri:level="4"><nlm:affiliation>Chromosome Research, Murdoch Childrens Research Institute, and Department of Paediatrics, Royal Children's Hospital, University of Melbourne, Parkville, VIC 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Chromosome Research, Murdoch Childrens Research Institute, and Department of Paediatrics, Royal Children's Hospital, University of Melbourne, Parkville, VIC 3052</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Kowarsky, Mark" sort="Kowarsky, Mark" uniqKey="Kowarsky M" first="Mark" last="Kowarsky">Mark Kowarsky</name><affiliation wicri:level="1"><nlm:affiliation>Bioinformatics Division, The Walter & Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Bioinformatics Division, The Walter & Eliza Hall Institute of Medical Research, Parkville, VIC 3052</wicri:regionArea><wicri:noRegion>VIC 3052</wicri:noRegion></affiliation></author><author><name sortKey="Lansdell, Ben" sort="Lansdell, Ben" uniqKey="Lansdell B" first="Ben" last="Lansdell">Ben Lansdell</name><affiliation wicri:level="1"><nlm:affiliation>Bioinformatics Division, The Walter & Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Bioinformatics Division, The Walter & Eliza Hall Institute of Medical Research, Parkville, VIC 3052</wicri:regionArea><wicri:noRegion>VIC 3052</wicri:noRegion></affiliation></author><author><name sortKey="Brookwell, Ross" sort="Brookwell, Ross" uniqKey="Brookwell R" first="Ross" last="Brookwell">Ross Brookwell</name><affiliation wicri:level="1"><nlm:affiliation>Sullivan Nicolaides Pathology, Indooroopilly, QLD 4068, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Sullivan Nicolaides Pathology, Indooroopilly, QLD 4068</wicri:regionArea><wicri:noRegion>QLD 4068</wicri:noRegion></affiliation></author><author><name sortKey="Myklebost, Ola" sort="Myklebost, Ola" uniqKey="Myklebost O" first="Ola" last="Myklebost">Ola Myklebost</name><affiliation wicri:level="1"><nlm:affiliation>Department of Tumor Biology, Oslo University Hospital, Norwegian Radium Hospital, Oslo 0424, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Tumor Biology, Oslo University Hospital, Norwegian Radium Hospital, Oslo 0424</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Meza Zepeda, Leonardo" sort="Meza Zepeda, Leonardo" uniqKey="Meza Zepeda L" first="Leonardo" last="Meza-Zepeda">Leonardo Meza-Zepeda</name><affiliation wicri:level="1"><nlm:affiliation>Department of Tumor Biology, Oslo University Hospital, Norwegian Radium Hospital, Oslo 0424, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Tumor Biology, Oslo University Hospital, Norwegian Radium Hospital, Oslo 0424</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Holloway, Andrew J" sort="Holloway, Andrew J" uniqKey="Holloway A" first="Andrew J" last="Holloway">Andrew J. Holloway</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Genomics, Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Genomics, Peter MacCallum Cancer Centre, East Melbourne, VIC 3002</wicri:regionArea><wicri:noRegion>VIC 3002</wicri:noRegion></affiliation></author><author><name sortKey="Pedeutour, Florence" sort="Pedeutour, Florence" uniqKey="Pedeutour F" first="Florence" last="Pedeutour">Florence Pedeutour</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Solid Tumors Genetics, Nice University Hospital, Nice 06107, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratory of Solid Tumors Genetics, Nice University Hospital, Nice 06107</wicri:regionArea><wicri:noRegion>06107</wicri:noRegion><wicri:noRegion>06107</wicri:noRegion></affiliation></author><author><name sortKey="Choo, K H Andy" sort="Choo, K H Andy" uniqKey="Choo K" first="K H Andy" last="Choo">K H Andy Choo</name><affiliation wicri:level="4"><nlm:affiliation>Chromosome Research, Murdoch Childrens Research Institute, and Department of Paediatrics, Royal Children's Hospital, University of Melbourne, Parkville, VIC 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Chromosome Research, Murdoch Childrens Research Institute, and Department of Paediatrics, Royal Children's Hospital, University of Melbourne, Parkville, VIC 3052</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Damore, Michael A" sort="Damore, Michael A" uniqKey="Damore M" first="Michael A" last="Damore">Michael A. Damore</name><affiliation wicri:level="2"><nlm:affiliation>Amgen, Thousand Oaks, CA 91320, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Amgen, Thousand Oaks, CA 91320</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Deans, Andrew J" sort="Deans, Andrew J" uniqKey="Deans A" first="Andrew J" last="Deans">Andrew J. Deans</name><affiliation wicri:level="1"><nlm:affiliation>St Vincent's Institute, Fitzroy, VIC 3065, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>St Vincent's Institute, Fitzroy, VIC 3065</wicri:regionArea><wicri:noRegion>VIC 3065</wicri:noRegion></affiliation></author><author><name sortKey="Papenfuss, Anthony T" sort="Papenfuss, Anthony T" uniqKey="Papenfuss A" first="Anthony T" last="Papenfuss">Anthony T. Papenfuss</name><affiliation wicri:level="4"><nlm:affiliation>Bioinformatics Division, The Walter & Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, VIC 3010, Australia; Department of Mathematics and Statistics, University of Melbourne, VIC, 3010, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, VIC 3010, Australia; Bioinformatics and Cancer Genomics, Peter MacCallum Cancer Centre, East Melbourne, VIC, 3002, Australia. Electronic address: papenfuss@wehi.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Bioinformatics Division, The Walter & Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, VIC 3010, Australia; Department of Mathematics and Statistics, University of Melbourne, VIC, 3010, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, VIC 3010, Australia; Bioinformatics and Cancer Genomics, Peter MacCallum Cancer Centre, East Melbourne, VIC, 3002</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Thomas, David M" sort="Thomas, David M" uniqKey="Thomas D" first="David M" last="Thomas">David M. Thomas</name><affiliation wicri:level="4"><nlm:affiliation>Cancer Genomics, Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, VIC 3010, Australia; The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia. Electronic address: d.thomas@garvan.org.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Genomics, Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, VIC 3010, Australia; The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, NSW 2010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author></analytic><series><title level="j">Cancer cell</title><idno type="eISSN">1878-3686</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Carcinogenesis (genetics)</term><term>Cell Line, Tumor</term><term>Centromere (genetics)</term><term>Chromosome Aberrations</term><term>Chromosomes, Human (genetics)</term><term>Female</term><term>Humans</term><term>Liposarcoma (genetics)</term><term>Liposarcoma (pathology)</term><term>Models, Genetic</term><term>Mutagenesis</term><term>Oncogenes</term><term>Retroperitoneal Neoplasms (genetics)</term><term>Retroperitoneal Neoplasms (pathology)</term><term>Translocation, Genetic</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Aberrations des chromosomes</term><term>Carcinogenèse (génétique)</term><term>Centromère (génétique)</term><term>Chromosomes humains (génétique)</term><term>Femelle</term><term>Humains</term><term>Lignée cellulaire tumorale</term><term>Liposarcome (anatomopathologie)</term><term>Liposarcome (génétique)</term><term>Modèles génétiques</term><term>Mutagenèse</term><term>Oncogènes</term><term>Sujet âgé</term><term>Translocation génétique</term><term>Tumeurs du rétropéritoine (anatomopathologie)</term><term>Tumeurs du rétropéritoine (génétique)</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Liposarcome</term><term>Tumeurs du rétropéritoine</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Carcinogenesis</term><term>Centromere</term><term>Chromosomes, Human</term><term>Liposarcoma</term><term>Retroperitoneal Neoplasms</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Carcinogenèse</term><term>Centromère</term><term>Chromosomes humains</term><term>Liposarcome</term><term>Tumeurs du rétropéritoine</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Liposarcoma</term><term>Retroperitoneal Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Cell Line, Tumor</term><term>Chromosome Aberrations</term><term>Female</term><term>Humans</term><term>Models, Genetic</term><term>Mutagenesis</term><term>Oncogenes</term><term>Translocation, Genetic</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Aberrations des chromosomes</term><term>Femelle</term><term>Humains</term><term>Lignée cellulaire tumorale</term><term>Modèles génétiques</term><term>Mutagenèse</term><term>Oncogènes</term><term>Sujet âgé</term><term>Translocation génétique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We isolated and analyzed, at single-nucleotide resolution, cancer-associated neochromosomes from well- and/or dedifferentiated liposarcomas. Neochromosomes, which can exceed 600 Mb in size, initially arise as circular structures following chromothripsis involving chromosome 12. The core of the neochromosome is amplified, rearranged, and corroded through hundreds of breakage-fusion-bridge cycles. Under selective pressure, amplified oncogenes are overexpressed, while coamplified passenger genes may be silenced epigenetically. New material may be captured during punctuated chromothriptic events. Centromeric corrosion leads to crisis, which is resolved through neocentromere formation or native centromere capture. Finally, amplification terminates, and the neochromosome core is stabilized in linear form by telomere capture. This study investigates the dynamic mutational processes underlying the life history of a special form of cancer mutation.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Norvège</li><li>États-Unis</li></country><region><li>Californie</li><li>Victoria (État)</li><li>Østlandet</li></region><settlement><li>Melbourne</li><li>Oslo</li></settlement><orgName><li>Université de Melbourne</li></orgName></list><tree><country name="Australie"><region name="Victoria (État)"><name sortKey="Garsed, Dale W" sort="Garsed, Dale W" uniqKey="Garsed D" first="Dale W" last="Garsed">Dale W. Garsed</name></region><name sortKey="Brookwell, Ross" sort="Brookwell, Ross" uniqKey="Brookwell R" first="Ross" last="Brookwell">Ross Brookwell</name><name sortKey="Choo, K H Andy" sort="Choo, K H Andy" uniqKey="Choo K" first="K H Andy" last="Choo">K H Andy Choo</name><name sortKey="Corbin, Vincent D A" sort="Corbin, Vincent D A" uniqKey="Corbin V" first="Vincent D A" last="Corbin">Vincent D A. Corbin</name><name sortKey="Deans, Andrew J" sort="Deans, Andrew J" uniqKey="Deans A" first="Andrew J" last="Deans">Andrew J. Deans</name><name sortKey="Di Stefano, Leon" sort="Di Stefano, Leon" uniqKey="Di Stefano L" first="Leon" last="Di Stefano">Leon Di Stefano</name><name sortKey="Feng, Zhi Ping" sort="Feng, Zhi Ping" uniqKey="Feng Z" first="Zhi-Ping" last="Feng">Zhi-Ping Feng</name><name sortKey="Holloway, Andrew J" sort="Holloway, Andrew J" uniqKey="Holloway A" first="Andrew J" last="Holloway">Andrew J. Holloway</name><name sortKey="Hsu, Arthur" sort="Hsu, Arthur" uniqKey="Hsu A" first="Arthur" last="Hsu">Arthur Hsu</name><name sortKey="Kim, Bo W" sort="Kim, Bo W" uniqKey="Kim B" first="Bo W" last="Kim">Bo W. Kim</name><name sortKey="Kowarsky, Mark" sort="Kowarsky, Mark" uniqKey="Kowarsky M" first="Mark" last="Kowarsky">Mark Kowarsky</name><name sortKey="Lansdell, Ben" sort="Lansdell, Ben" uniqKey="Lansdell B" first="Ben" last="Lansdell">Ben Lansdell</name><name sortKey="Li, Jason" sort="Li, Jason" uniqKey="Li J" first="Jason" last="Li">Jason Li</name><name sortKey="Marshall, Owen J" sort="Marshall, Owen J" uniqKey="Marshall O" first="Owen J" last="Marshall">Owen J. Marshall</name><name sortKey="Papenfuss, Anthony T" sort="Papenfuss, Anthony T" uniqKey="Papenfuss A" first="Anthony T" last="Papenfuss">Anthony T. Papenfuss</name><name sortKey="Schroder, Jan" sort="Schroder, Jan" uniqKey="Schroder J" first="Jan" last="Schröder">Jan Schröder</name><name sortKey="Thomas, David M" sort="Thomas, David M" uniqKey="Thomas D" first="David M" last="Thomas">David M. Thomas</name></country><country name="Norvège"><region name="Østlandet"><name sortKey="Myklebost, Ola" sort="Myklebost, Ola" uniqKey="Myklebost O" first="Ola" last="Myklebost">Ola Myklebost</name></region><name sortKey="Meza Zepeda, Leonardo" sort="Meza Zepeda, Leonardo" uniqKey="Meza Zepeda L" first="Leonardo" last="Meza-Zepeda">Leonardo Meza-Zepeda</name></country><country name="France"><noRegion><name sortKey="Pedeutour, Florence" sort="Pedeutour, Florence" uniqKey="Pedeutour F" first="Florence" last="Pedeutour">Florence Pedeutour</name></noRegion></country><country name="États-Unis"><region name="Californie"><name sortKey="Damore, Michael A" sort="Damore, Michael A" uniqKey="Damore M" first="Michael A" last="Damore">Michael A. 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